Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets.
作者： Nunzio Pomara , John J Sidtis
DOI: 10.1111/J.1476-5381.2010.00948.X
关键词:
摘要: The monoamine hypothesis ascribes an important role to the underactivity of brain monoamines such as 5-HT, noradrenaline and dopamine pathophysiology depression. This view emerged more than 50 years ago has guided development most medications currently used for treatment this disorder. However, large numbers depressed individuals treated with available antidepressant agents, or even various combinations, do not respond. Residual symptoms, relapses recurrences are common while receiving adequate doses these medications. In a recent issue BJP, Colaianna et al. describe results suggesting that new neurobiological mechanism implications should be considered depression in humans, namely, elevations potentially neurotoxic amyloid-β peptides. LINKED ARTICLE To paper by visit http://dx.doi.org/10.1111/j.1476-5381.2010.00669.x
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