Aminothiazoles and their use as adenosine receptor antagonists
作者： Roger John Horsham Taylor , Neil John Horsham Press
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摘要: Compounds of formula (I) in free or salt form, where A is a C6-C15 monovalent aromatic group. R1 hydrogen, phenyl optionally substituted by one more substituents selected from halogen, cyano, hydroxy, C?1?-C8-alkyl, C1-C8-haloalkyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl acyloxy, 5- 6- membered heterocyclic group, R?2? C?1-?C8-alkyl, acyl CON(R?3)R4?, provided that R2 C1-C8-alkyl, CON(R?3)R4 when R1? R?3 and R4? are each independently together with the nitrogen atom to which they attached denote Z?1, Z2, Z3 Z4? N CR5, at least them being CR?5, R5? C?1?-C8-alkyl C1-C8-alkoxy. The compounds useful as adenosine receptor antagonists, particularly treatment inflammatory obstrucive airways diseases.
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