Vascular function, cerebral cortical thickness, and cognitive performance in middle-aged Hispanic and non-Hispanic Caucasian adults.

摘要: Hispanics are at increased risk for acquiring cardiovascular factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures cerebral gray matter integrity, 60 middle-aged Hispanic and non-Hispanic Caucasian participants were matched across age, sex, years education, mental status. Arterial stiffness was characterized by β-stiffness index carotid-femoral pulse wave velocity, magnetic resonance imaging estimated cortical thickness in a priori regions interest known be susceptible factors. Measures arterial significantly higher than Caucasians. exhibited thinner left inferior frontal gyrus (LIFG) (P=.04) concurrently lower language (P=.02), memory (P=.03), attention-executive functioning (P=.02). These results suggest compromised may occur simultaneously thinning the LIFG as an early neuropathological alteration Hispanics.