Cholinergic mechanisms in physical dependence on barbiturates, ethanol and benzodiazepines

摘要: The aim of this review is to summarize the effects acute and chronic treatment with barbiturates, ethanol benzodiazepines on cholinergic mechanisms in brains experimental animals. A single dose each these substances reduces turnover ACh brain. Long-term has opposite effect; complicated interactions including decreased content are induced. Barbiturates have been shown bind stereospecifically muscarinic nicotinic receptors brain, but not observed for or benzodiazepines. system affected by length choice regimen. No effect parameters, such as receptors, brain withdrawal barbiturate when animals still tolerant towards substances. increase number several regions seen a sign supersensitivity. returns normal abstinence convulsions occurred. assumption influence supported finding that atropine, given day barbital, can prevent receptor changes. Furthermore, long-term barbital induce permanent persistent changes Cognitive defects significant reduction be measured rats which had treatment. Similarly, reduced different alcoholics. Accumulating data support role expressing symptoms physical dependence well after end