The effects of intrathecal administration of the dopamine agonist apomorphine on penile reflexes and copulation in the male rat

作者: Elizabeth A. Pehek , James T. Thompson , Elaine M. Hull

DOI: 10.1007/BF00445548

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摘要: Relatively high doses of systemically administered apomorphine inhibit penile reflexes. It is possible that these inhibitory effects are due, at least in part, to actions on the lumbosacral spinal cord. The present experiments examined this possibility by injecting (10 and 50 micrograms/5.0 microliters vehicle) into subarachnoid space through chronic, indwelling cannulae. Such injections impaired ex copula reflexes, slowed rate copulation, decreased number intromissions preceding ejaculation. These results suggest cord dopamine receptors may normally regulate male sexual performance.

参考文章(23)
T J Bazzett, L L Scaletta, J T Thompson, E M Hull, R K Warner, R C Eaton, D2/D1 ratio in the medial preoptic area affects copulation of male rats. Journal of Pharmacology and Experimental Therapeutics. ,vol. 251, pp. 422- 427 ,(1989)
Marcia L. Stefanick, Erla R. Smith, John T. Clark, Julian M. Davidson, Effects of a potent dopamine receptor agonist, RDS-127, on penile reflexes and seminal emission in intact and spinally transected rats Physiology & Behavior. ,vol. 29, pp. 973- 978 ,(1982) , 10.1016/0031-9384(82)90286-4
L. Svensson, S. Hansen, Spinal monoaminergic modulation of masculine copulatory behavior in the rat. Brain Research. ,vol. 302, pp. 315- 321 ,(1984) , 10.1016/0006-8993(84)90245-2
Alma J. Gower, Hemmie H.G. Berendsen, Martin M. Princen, Chris L.E. Broekkamp, The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity European Journal of Pharmacology. ,vol. 103, pp. 81- 89 ,(1984) , 10.1016/0014-2999(84)90192-4
R LOPACHIN, T RUDY, T YAKSH, An improved method for chronic catheterization of the rat spinal subarachnoid space Physiology & Behavior. ,vol. 27, pp. 559- 561 ,(1981) , 10.1016/0031-9384(81)90350-4
Benjamin L. Hart, Sexual reflexes and mating behavior in the male dog. Journal of Comparative and Physiological Psychology. ,vol. 64, pp. 388- 399 ,(1967) , 10.1037/H0025222
John T. Clark, Erla R. Smith, Effects of apomorphine on sexual behavior in young and middle-aged rats. Neurobiology of Aging. ,vol. 8, pp. 153- 157 ,(1987) , 10.1016/0197-4580(87)90025-X