Receptor Tyrosine Phosphatase-δ Is a Homophilic, Neurite-Promoting Cell Adhesion Molecule for CNS Neurons
作者： J. Wang , J.L. Bixby
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摘要: Abstract Appropriate regulation of tyrosine phosphorylation is essential for axon growth and guidance; evidence from invertebrates indicates that receptor-type phosphatases (RPTPs) are required correct during CNS development. One vertebrate RPTP, PTP-δ, highly expressed in brain has a cell adhesion molecule-like extracellular domain (ECD) comprising three immunoglobulin repeats eight fibronectin type III repeats. Using fluorescent beads (Covaspheres) coated with the PTP-δ ECD, as well insect cells expressing on their surfaces, we show homophilic molecule. A variety chick neurons adhere strongly to an Fc fusion protein containing ECD. Additionally, substrate-bound ECD promotes neurite outgrowth forebrain neurons; this effect separable its adhesion. Our results indicate neurite-promoting molecule neurons.
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