Modulation of red cell mass by neocytolysis in space and on Earth.

摘要: Astronauts predictably experience anemia after return from space. Upon entering microgravity, the blood volume in extremities pools centrally and plasma decreases, causing plethora erythropoietin suppression. There ensues neocytolysis, selective hemolysis of youngest circulating red cells, allowing rapid adaptation to space environment but becoming maladaptive on re-entry a gravitational field. The existence this physiologic control process was confirmed polycythemic high-altitude dwellers transported sea level. Pathologic neocytolysis contributes renal failure. Understanding has implications for optimizing erythropoietin-dosing schedules therapy other human disorders. Human rodent models are being created help find out how interactions between endothelial reticuloendothelial phagocytes young erythrocytes altered, shed light expression surface adhesion molecules underlying process. Thus, unraveling problem travelers uncovered controlling cell mass that can be applied disorders Earth.