Eradication of invasive mucormycosis--effectiveness of the Echinocandin FK463.

摘要: Abstract Background: Invasive rhinocerebral mucormycosis is a rare and often fatal opportunistic fungal infection. It encountered in immunocompromised hosts exemplified by those with diabetes, human immunodeficiency viruses particularly haematologic malignancies typically after high-dose chemotherapy stem cell transplantation. In contrast to the more usual outcome rapid progression death. We now describe successful eradication attributable use of newly available antifungal agent. Setting: Haematology department bone marrow transplantation unit. Material method: Two patients are contrasted. The first acute leukaemia developed rapidly progressive facial swelling proven on biopsy. Treatment over 2 months maximally tolerated doses amphotericin failed halt intracranial extension death resulted. second, presented lymphoblastic August 1997, underwent autologous Februa...