Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis.

摘要: PURPOSE: To investigate the influence of aging on conventional magnetic resonance (MR) imaging–, magnetization transfer MR and diffusion-tensor imaging–derived measurements. MATERIALS AND METHODS: Dual-echo T1-weighted images brain were obtained in 89 healthy subjects. Normalized parenchymal volume (NBV) was measured by using a fully automated technique. Magnetization ratio (MTR), apparent diffusion coefficient (ADC), fractional anisotropy (FA) histograms created for whole (MTR values) or large representative portion it (ADC FA values). Bivariate correlations assessed Spearman rank correlation coefficient. A stepwise selection procedure used to identify combination variables that most influenced subject age multivariate regression model. RESULTS: Significant found between following variables: number hyperintense...