Systems biology: parameter estimation for biochemical models

摘要: Mathematical models of biological processes have various applications: to assist in understanding the functioning a system, simulate experiments before actually performing them, study situations that cannot be dealt with experimentally, etc. Some parameters model can directly obtained from or literature. Others inferred by comparing results experiments. In this minireview, we discuss identifiability models, both intrinsic and taking into account available data. Furthermore, give an overview most frequently used approaches search parameter space.