作者: Xiaofeng Zhou , Nagesh P. Rao , Steven W. Cole , David T. Wong
DOI: 10.1007/978-1-59745-576-3_7
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摘要: Tumors develop through the combined processes of genetic instability and selection, resulting in clonal expansion cells that have accumulated most advantageous set aberrations. These instabilities manifest themselves as a series alterations, including discrete mutations chromosomal With human genome deciphered, high-throughput technologies are advancing studies to link genome-wide gene expression mutation profiles with biological disease phenotypes. Recent advances comprehensive genomic characterization present an unprecedented opportunity for treatment cancer, but many challenges remain be overcome before we can fully exploit markers/targets cancer prediction, diagnosis, prognostics. Here, review recent developments at DNA level, consider some defining precise portrait tumors. We then offer potential solutions may help these challenges.