Comprehensive Genomic Profiling for Biomarker Discovery for Cancer Detection, Diagnostics and Prognostics

作者: Xiaofeng Zhou , Nagesh P. Rao , Steven W. Cole , David T. Wong

DOI: 10.1007/978-1-59745-576-3_7

关键词:

摘要: Tumors develop through the combined processes of genetic instability and selection, resulting in clonal expansion cells that have accumulated most advantageous set aberrations. These instabilities manifest themselves as a series alterations, including discrete mutations chromosomal With human genome deciphered, high-throughput technologies are advancing studies to link genome-wide gene expression mutation profiles with biological disease phenotypes. Recent advances comprehensive genomic characterization present an unprecedented opportunity for treatment cancer, but many challenges remain be overcome before we can fully exploit markers/targets cancer prediction, diagnosis, prognostics. Here, review recent developments at DNA level, consider some defining precise portrait tumors. We then offer potential solutions may help these challenges.

参考文章(77)
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
Xiaofeng Zhou, Steven W. Cole, Shen Hu, David T. W. Wong, Detection of DNA copy number abnormality by microarray expression analysis. Human Genetics. ,vol. 114, pp. 464- 467 ,(2004) , 10.1007/S00439-004-1087-9
Thomas Liehr, Anita Heller, Heike Starke, Uwe Claussen, FISH banding methods: applications in research and diagnostics. Expert Review of Molecular Diagnostics. ,vol. 2, pp. 217- 225 ,(2002) , 10.1586/14737159.2.3.217
Jonathan J. Davies, Ian M. Wilson, Wan L. Lam, Array CGH technologies and their applications to cancer genomes. Chromosome Research. ,vol. 13, pp. 237- 248 ,(2005) , 10.1007/S10577-005-2168-X
Donna G Albertson, Colin Collins, Frank McCormick, Joe W Gray, Chromosome aberrations in solid tumors. Nature Genetics. ,vol. 34, pp. 369- 376 ,(2003) , 10.1038/NG1215
Marek Liyanage, Allen Coleman, Stan du Manoir, Tim Veldman, Stephen McCormack, Robert B. Dickson, Carrolee Barlow, Anthony Wynshaw-Boris, Siegfried Janz, Johannes Wienberg, Malcolm A. Ferguson-Smith, Evelin Schröck, Thomas Ried, Multicolour spectral karyotyping of mouse chromosomes. Nature Genetics. ,vol. 14, pp. 312- 315 ,(1996) , 10.1038/NG1196-312
Päivikki Kauraniemi, Tuula Kuukasjärvi, Guido Sauter, Anne Kallioniemi, Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer. American Journal of Pathology. ,vol. 163, pp. 1979- 1984 ,(2003) , 10.1016/S0002-9440(10)63556-0
Michael R. Speicher, Stephen Gwyn Ballard, David C. Ward, Karyotyping human chromosomes by combinatorial multi-fluor FISH Nature Genetics. ,vol. 12, pp. 368- 375 ,(1996) , 10.1038/NG0496-368
A. G. Knudson, Mutation and Cancer: Statistical Study of Retinoblastoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 68, pp. 820- 823 ,(1971) , 10.1073/PNAS.68.4.820
Xiaofeng Zhou, Tianwei Yu, Steven W Cole, David TW Wong, Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer. Expert Review of Molecular Diagnostics. ,vol. 6, pp. 39- 50 ,(2006) , 10.1586/14737159.6.1.39