Ancient genomes reveal structural shifts after the arrival of Steppe-related ancestry in the Italian Peninsula
作者： Christiana L. Scheib , Christiana L. Scheib , Letizia Silvestri , Toomas Kivisild , Toomas Kivisild
DOI: 10.1016/J.CUB.2021.04.022
关键词:
摘要: Summary Across Europe, the genetics of Chalcolithic/Bronze Age transition is increasingly characterized in terms an influx Steppe-related ancestry. The effect this major shift on genetic structure populations Italian Peninsula remains underexplored. Here, genome-wide shotgun data for 22 individuals from commingled cave and single burials Northeastern Central Italy dated between 3200 1500 BCE provide first genomic characterization Bronze (n = 8; 0.001–1.2× coverage) central Peninsula, filling a gap literature 1950 BCE. Our study confirms diversity ancestry components during Chalcolithic arrival as early 1600 BCE, with component increasing through time. We detect close patrilineal kinship burial patterns away (2200–900 BCE) along lowered runs homozygosity, which may reflect larger changes population structure. Finally, we find no evidence that directly led to frequency 115 phenotypes present dataset, rather post-Roman Imperial period had stronger influence, particularly variants associated protection against Hansen’s disease (leprosy). provides closer look at local dynamics demography phenotypic shifts they occurred part broader phenomenon widespread admixture transition.
sci-hub.st 参考文章(122)
T A Brown, D E Nelson, J S Vogel, J R Southon, Improved collagen extraction by modified Longin method Radiocarbon. ,vol. 30, pp. 171- 177 ,(1988) , 10.1017/S0033822200044118
Morten E. Allentoft, Martin Sikora, Karl-Göran Sjögren, Simon Rasmussen, Morten Rasmussen, Jesper Stenderup, Peter B. Damgaard, Hannes Schroeder, Torbjörn Ahlström, Lasse Vinner, Anna-Sapfo Malaspinas, Ashot Margaryan, Tom Higham, David Chivall, Niels Lynnerup, Lise Harvig, Justyna Baron, Philippe Della Casa, Paweł Dąbrowski, Paul R. Duffy, Alexander V. Ebel, Andrey Epimakhov, Karin Frei, Mirosław Furmanek, Tomasz Gralak, Andrey Gromov, Stanisław Gronkiewicz, Gisela Grupe, Tamás Hajdu, Radosław Jarysz, Valeri Khartanovich, Alexandr Khokhlov, Viktória Kiss, Jan Kolář, Aivar Kriiska, Irena Lasak, Cristina Longhi, George McGlynn, Algimantas Merkevicius, Inga Merkyte, Mait Metspalu, Ruzan Mkrtchyan, Vyacheslav Moiseyev, László Paja, György Pálfi, Dalia Pokutta, Łukasz Pospieszny, T. Douglas Price, Lehti Saag, Mikhail Sablin, Natalia Shishlina, Václav Smrčka, Vasilii I. Soenov, Vajk Szeverényi, Gusztáv Tóth, Synaru V. Trifanova, Liivi Varul, Magdolna Vicze, Levon Yepiskoposyan, Vladislav Zhitenev, Ludovic Orlando, Thomas Sicheritz-Pontén, Søren Brunak, Rasmus Nielsen, Kristian Kristiansen, Eske Willerslev, Population genomics of Bronze Age Eurasia Nature. ,vol. 522, pp. 167- 172 ,(2015) , 10.1038/NATURE14507
Sahra Talamo, Mike Richards, A Comparison of Bone Pretreatment Methods for AMS Dating of Samples >30,000 BP Radiocarbon. ,vol. 53, pp. 443- 449 ,(2011) , 10.1017/S0033822200034573
George B.J. Busby, Garrett Hellenthal, Francesco Montinaro, Sergio Tofanelli, Kazima Bulayeva, Igor Rudan, Tatijana Zemunik, Caroline Hayward, Draga Toncheva, Sena Karachanak-Yankova, Desislava Nesheva, Paolo Anagnostou, Francesco Cali, Francesca Brisighelli, Valentino Romano, Gerard Lefranc, Catherine Buresi, Jemni Ben Chibani, Amel Haj-Khelil, Sabri Denden, Rafal Ploski, Pawel Krajewski, Tor Hervig, Torolf Moen, Rene J. Herrera, James F. Wilson, Simon Myers, Cristian Capelli, The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape. Current Biology. ,vol. 25, pp. 2518- 2526 ,(2015) , 10.1016/J.CUB.2015.08.007
Iñigo Olalde, Morten E. Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W. K. Chiang, Michael DeGiorgio, Javier Prado-Martinez, Juan Antonio Rodríguez, Simon Rasmussen, Javier Quilez, Oscar Ramírez, Urko M. Marigorta, Marcos Fernández-Callejo, María Encina Prada, Julio Manuel Vidal Encinas, Rasmus Nielsen, Mihai G. Netea, John Novembre, Richard A. Sturm, Pardis Sabeti, Tomàs Marquès-Bonet, Arcadi Navarro, Eske Willerslev, Carles Lalueza-Fox, Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European Nature. ,vol. 507, pp. 225- 228 ,(2014) , 10.1038/NATURE12960
G.J. van Klinken, Bone Collagen Quality Indicators for Palaeodietary and Radiocarbon Measurements Journal of Archaeological Science. ,vol. 26, pp. 687- 695 ,(1999) , 10.1006/JASC.1998.0385
Hui Qi, Lin Sun, Xirong Wu, Yaqiong Jin, Jing Xiao, Shengfeng Wang, Chen Shen, Ping Chu, Zhan Qi, Fang Xu, Yajie Guo, Weiwei Jiao, Jianling Tian, Adong Shen, Toll-like receptor 1(TLR1) Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children. Tuberculosis. ,vol. 95, pp. 197- 203 ,(2015) , 10.1016/J.TUBE.2014.12.001
Bishwa R. Sapkota, Murdo Macdonald, William R. Berrington, E. Ann Misch, Chaman Ranjit, M. Ruby Siddiqui, Gilla Kaplan, Thomas R. Hawn, Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes Human Immunology. ,vol. 71, pp. 992- 998 ,(2010) , 10.1016/J.HUMIMM.2010.07.001
Doron M. Behar, Mannis van Oven, Saharon Rosset, Mait Metspalu, Eva-Liis Loogväli, Nuno M. Silva, Toomas Kivisild, Antonio Torroni, Richard Villems, A "copernican" reassessment of the human mitochondrial DNA tree from its root American Journal of Human Genetics. ,vol. 90, pp. 675- 684 ,(2012) , 10.1016/J.AJHG.2012.03.002
R. LONGIN, New Method of Collagen Extraction for Radiocarbon Dating Nature. ,vol. 230, pp. 241- 242 ,(1971) , 10.1038/230241A0