Unravelling the relationship between protein sequence and low-complexity regions entropies: Interactome implications

摘要: Low-complexity regions are sub-sequences of biased composition in a protein sequence. The influence these over evolution, specific functions and highly interactive capacities is well known. Although sequence entropy has been largely studied, its relationship with low-complexity the subsequent effects on function remains unclear. In this work we propose theoretical empirical model integrating local complexity parameters. Our results indicate that related length, entropies inside outside as their number average size. We found small but significant increment hubs proteins. agreement our model, dependent balance between length size regions. Finally, models proteins analysis provide evidence supporting modifications more relevant than changes