Systemic Therapy of Bone Metastases

摘要: A few solid tumors have the propensity to bone and they can form two distinct types of lesions, which depend on whether osteoclastic (breast thyroid cancer) or osteoblastic (prostate activity prevails. Regardless lesion, metastazing cancers usually behave indolently share in common significant sensitivity hormone therapies. The efficacy chemotherapy is limited, it depends tumor type. In general marrow-sparing strategies as are weekly schedules metronomic appears be most appropriate therapeutic approach for patients with metastases. Hormonotherapy hormone-sensitive metastases typically shown effective over protracted periods time outperforms benefiting these patients. Therefore hormonotherapy should considered an upfront treatment option such cancers. Cancer research currently investigating molecular mechanisms, underlie apparent close ties hormonal driven microenvironment bone. Improvements biological understanding hoped boost clinical into developing optimal management sensitive