Development and application of Hsp90 inhibitors

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Tamas Korcsmaros, Peter Csermely, Katalin Sulyok, Stress responses in biology and medicine : stress of life in molecules, cells, organisms, and psychosocial communities Blackwell Pub. on behalf of the New York Academy of Sciences. ,(2007)

David B. Solit, Carlos Cordon-Cardo, David Verbel, Howard I. Scher, Brian Higgins, Neal Rosen, Pamela N. Münster, Fuzhong F. Zheng, David B. Agus, Maria Drobnjak, Glenn Heller, William Tong, 17-Allylamino-17-demethoxygeldanamycin Induces the Degradation of Androgen Receptor and HER-2/neu and Inhibits the Growth of Prostate Cancer Xenografts Clinical Cancer Research. ,vol. 8, pp. 986- 993 ,(2002)

Peter M. Smith-Jones, David Solit, Neal Rosen, Farzana Afroze, Steven M. Larson, Early Tumor Response to Hsp90 Therapy Using HER2 PET: Comparison with 18F-FDG PET The Journal of Nuclear Medicine. ,vol. 47, pp. 793- 796 ,(2006)

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Maria Vilenchik, David Solit, Andrea Basso, Henri Huezo, Brian Lucas, Huazhong He, Neal Rosen, Claudia Spampinato, Paul Modrich, Gabriela Chiosis, Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chemistry & Biology. ,vol. 11, pp. 787- 797 ,(2004) , 10.1016/J.CHEMBIOL.2004.04.008

O. M. Grbovic, A. D. Basso, A. Sawai, Q. Ye, P. Friedlander, D. Solit, N. Rosen, V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 57- 62 ,(2006) , 10.1073/PNAS.0609973103

Adeela Kamal, Lia Thao, John Sensintaffar, Lin Zhang, Marcus F. Boehm, Lawrence C. Fritz, Francis J. Burrows, A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors Nature. ,vol. 425, pp. 407- 410 ,(2003) , 10.1038/NATURE01913

Edward G. Mimnaugh, Christine Chavany, Len Neckers, Polyubiquitination and Proteasomal Degradation of the p185c-erbB-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin Journal of Biological Chemistry. ,vol. 271, pp. 22796- 22801 ,(1996) , 10.1074/JBC.271.37.22796

Chad A. Dickey, Adeela Kamal, Karen Lundgren, Natalia Klosak, Rachel M. Bailey, Judith Dunmore, Peter Ash, Sareh Shoraka, Jelena Zlatkovic, Christopher B. Eckman, Cam Patterson, Dennis W. Dickson, N. Stanley Nahman, Michael Hutton, Francis Burrows, Leonard Petrucelli, The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins Journal of Clinical Investigation. ,vol. 117, pp. 648- 658 ,(2007) , 10.1172/JCI29715