Affibody molecules as engineered protein drugs

作者: Fredrik Y Frejd , Kyu-Tae Kim

DOI: 10.1038/EMM.2017.35

关键词:

摘要: Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on use of this class alternative scaffolds, early clinical evidence is now beginning to accumulate that suggests the efficacious safe man. The small size ease engineering make suitable multispecific constructs where AffiMabs one such offers option potentiate antibodies complex disease.

参考文章(93)
Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch, Alfred Sandrock, The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease Nature. ,vol. 537, pp. 50- 56 ,(2016) , 10.1038/NATURE19323
Javad Garousi, Hadis Honarvar, Ken G. Andersson, Bogdan Mitran, Anna Orlova, Jos Buijs, John Löfblom, Fredrik Y. Frejd, Vladimir Tolmachev, Comparative Evaluation of Affibody Molecules for Radionuclide Imaging of in Vivo Expression of Carbonic Anhydrase IX Molecular Pharmaceutics. ,vol. 13, pp. 3676- 3687 ,(2016) , 10.1021/ACS.MOLPHARMACEUT.6B00502
Magdalena Malm, Fredrik Y. Frejd, Stefan Ståhl, John Löfblom, Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds mAbs. ,vol. 8, pp. 1195- 1209 ,(2016) , 10.1080/19420862.2016.1212147
Maurizio Pompili, Marco Innamorati, Sara Trovarelli, Alessandra Narcisi, Samantha Bellini, Diego Orsini, Alberto Forte, Denise Erbuto, Elisabetta Botti, Dorian A Lamis, Paolo Girardi, Antonio Costanzo, Suicide risk and psychiatric comorbidity in patients with psoriasis Journal of International Medical Research. ,vol. 44, pp. 61- 66 ,(2016) , 10.1177/0300060515593253
Molly Campa, Alan Menter, A review of emerging IL-17 inhibitors in the treatment of psoriasis focusing on preclinical through phase II studies Expert Opinion on Investigational Drugs. ,vol. 25, pp. 1337- 1344 ,(2016) , 10.1080/13543784.2016.1237502
Ken G. Andersson, Maryam Oroujeni, Javad Garousi, Bogdan Mitran, Stefan Ståhl, Anna Orlova, John Löfblom, Vladimir Tolmachev, Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR:2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator International Journal of Oncology. ,vol. 49, pp. 2285- 2293 ,(2016) , 10.3892/IJO.2016.3721
Judit Nyirady, Andrew Blauvelt, Alice B Gottlieb, Jörg C Prinz, Todd Fox, Charis Papavassilis, Philemon Papanastasiou, Rashidkhan Pathan, Secukinumab Self-Administration by Prefilled Syringe Maintains Reduction of Plaque Psoriasis Severity Over 52 Weeks: Results of the FEATURE Trial Journal of Drugs in Dermatology. ,vol. 15, pp. 1226- 1234 ,(2016)
Jonathan T. Elliott, Kayla Marra, Linton T. Evans, Scott C. Davis, Kimberley S. Samkoe, Joachim Feldwisch, Keith D. Paulsen, David W. Roberts, Brian W. Pogue, Simultaneous In Vivo Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma. Clinical Cancer Research. ,vol. 23, pp. 2203- 2212 ,(2017) , 10.1158/1078-0432.CCR-16-1400
Josef S Smolen, Gerd-Rüdiger Burmester, Bernard Combe, Jeffrey R Curtis, Stephen Hall, Boulos Haraoui, Ronald van Vollenhoven, Christopher Cioffi, Cécile Ecoffet, Leon Gervitz, Lucian Ionescu, Luke Peterson, Roy Fleischmann, Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE study The Lancet. ,vol. 388, pp. 2763- 2774 ,(2016) , 10.1016/S0140-6736(16)31651-8
Kimberley S. Samkoe, Jason R. Gunn, Kayla Marra, Sally M. Hull, Karen L. Moodie, Joachim Feldwisch, Theresa V. Strong, Daniel R. Draney, P. Jack Hoopes, David W. Roberts, Keith Paulsen, Brian W. Pogue, Toxicity and Pharmacokinetic Profile for Single-Dose Injection of ABY-029: a Fluorescent Anti-EGFR Synthetic Affibody Molecule for Human Use Molecular Imaging and Biology. ,vol. 19, pp. 512- 521 ,(2017) , 10.1007/S11307-016-1033-Y