A cadmium-resistant variant of the Chinese hamster (CHO) cell with increased metallothionein induction capacity.
作者： C.E. Hildebrand , R.A. Tobey , E.W. Campbell , M.D. Enger
DOI: 10.1016/0014-4827(79)90199-X
关键词:
摘要: Abstract The toxic trace metal Cd 2+ has been used to select a variant (designated r ) of the Chinese hamster cell (line CHO) resistant growth-inhibitory and cytotoxic effects . Resistance -mediated cytotoxicity is not due decreased capability accumulate since uptake in indistinguishable from that CHO at both subtoxic exposures. Comparison relative capacities these two types induce specific low molecular weight -binding proteins (metallothioneins) reveals an increased capacity metallothionein sequester intracellular metallothioneins. These results suggest greater competence major factor -resistant phenotype variant.
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