Physiological Relevance of Cell Cycle Kinases
作者： Marcos Malumbres
DOI: 10.1152/PHYSREV.00025.2010
关键词:
摘要: The basic biology of the cell division cycle and its control by protein kinases was originally studied through genetic biochemical studies in yeast other model organisms. major regulatory mechanisms identified this pioneer work are conserved mammals. However, recent different types or models now providing a new perspective on function these regulators tissues. Here, we review physiological relevance mammalian such as cyclin-dependent (Cdks), Aurora Polo-like kinases, mitotic checkpoint (Bub1, BubR1, Mps1) well less-studied enzymes Cdc7, Nek proteins, Mastl their implications development, tissue homeostasis, human disease. Among functions, self-renewal asymmetric stem/progenitor cells ability to regenerate injured tissues is central issue current research. In addition, many proteins play previously unexpected roles metabolism, cardiovascular function, neuron biology. modulation enzymatic activity may therefore have multiple therapeutic benefits
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