Metal‐Regulated Gene Expression
作者： A.J. Guerra , D.P. Giedroc
DOI: 10.1016/B978-0-08-097774-4.00305-3
关键词:
摘要: The chemistry of transition‐metal ions makes them both essential cofactors to vital processes in the cell as well a source reactive oxygen species that can have lethal consequences. genes encoding proteins collectively manage cellular metal ion homeostasis are under transcriptional control metalloregulatory harbor metal-specific coordination sites allosterically regulate operator DNA binding. This chapter reviews recent efforts understand protein structure, chemistry, and structural mechanisms metal-dependent gene expression prokaryotes eukaryotes.
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