Flecainide versus quinidine for conversion of atrial fibrillation to sinus rhythm.

摘要: The effectiveness and safety of flecainide quinidine for conversion atrial fibrillation (AF) to sinus rhythm were compared. Sixty consecutive patients treated with either (up 2 mg/kg intravenously then orally) or 1.2 g orally). There was no statistical difference in age, left size, duration the arrhythmia underlying cardiac diseases between groups. overall rate 63% (38 patients): AF converted 18 (60%) 20 (67%) flecainide. If lasted less than 10 days, 86% group 80% (difference not significant). When more days 22% 40% group. Adverse effects frequent (27%) (gastrointestinal disturbances) (7%) (conduction disturbances), but they severe Thus, given appeared be as effective orally recent onset (within days). However, should probably remain preferred drug long (more days) rhythm. occurred often therapy, severe.