Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

摘要: The effect of a polyanionic variably substituted sulfobutyl ether-β-cyclodextrin (SBE-β-CyD), complexation on the UV absorption genistein (Gen) and daidzein (Dai) was studied in pure water. A phase solubility study performed, according to method reported by Higuchi Connors, evaluate changes isoflavones state type-AL diagrams for both were obtained suggesting that they form complexes with 1:1 molar ratio. These results confirmed Job’s plot method. Complexation strongly increases water isoflavones. vitro dissolution entrapped into SBE-β-CyD significantly surpassed free (over 90 % loaded Gen Dai dissolved 15 30 min, respectively). Finally, ratio solid prepared kneading characterized FTIR-ATR spectroscopy, particular regard O–H C=O stretching vibrations, achieving structural information modifications induced H-bond scheme, also applying band decomposition curve-fit.