Obstructive hypertrophic cardiomyopathy is associated with enhanced thrombin generation and platelet activation
作者： P P Dimitrow , A Undas , M Bober , W Tracz , J S Dubiel
关键词:
摘要: Objectives: To investigate the association of left ventricular outflow tract (LVOT) obstruction with blood coagulation, platelet activity and inflammatory response in patients hypertrophic cardiomyopathy (HCM) sinus rhythm. Patients main outcome measures: In 42 HCM rhythm, including 16 resting LVOT (gradient ⩾30 mm Hg) 29 age- sex-matched controls, markers thrombin generation (thrombin–antithrombin complex (TAT), prothrombin fragment 1+2 (F1+2)), activation (soluble CD40 ligand (sCD40L), β-thromboglobulin (β-TG), P-selectin) inflammation (C-reactive protein (CRP), interleukin (IL)6, tumour necrosis factor-α (TNFα)) were determined. Results: Thrombin, higher entire group than controls (p r from 0.39 to 0.73; p R 2 = 0.61; = 0.59; = 0.55; p = 0.002), P-selectin ( = 0.49; p = 0.004) β-TG = 0.38; p = 0.005) HCM. Conclusions: is independently associated enhanced
sci-hub.se 参考文章(24)
Franco Cecchi, Iacopo Olivotto, Barry J. Maron, Other Modes of Disability or Death Including Stroke, and Treatment Strategies, in Hypertrophic Cardiomyopathy Diagnosis and Management of Hypertrophic Cardiomyopathy. pp. 121- 131 ,(2007) , 10.1002/9780470987469.CH7
Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. ,vol. 93, pp. 841- 842 ,(1996) , 10.1161/01.CIR.93.5.841
Pȧl Aukrust, Jan Kristian Damȧs, Nils Olav Solum, Soluble CD40 ligand and platelets: self-perpetuating pathogenic loop in thrombosis and inflammation? Journal of the American College of Cardiology. ,vol. 43, pp. 2326- 2328 ,(2004) , 10.1016/J.JACC.2004.03.023
Charles T. Esmon, The interactions between inflammation and coagulation British Journal of Haematology. ,vol. 131, pp. 417- 430 ,(2005) , 10.1111/J.1365-2141.2005.05753.X
Iacopo Olivotto, Franco Cecchi, Susan A. Casey, Alberto Dolara, Jay H. Traverse, Barry J. Maron, Impact of Atrial Fibrillation on the Clinical Course of Hypertrophic Cardiomyopathy Circulation. ,vol. 104, pp. 2517- 2524 ,(2002) , 10.1161/HC4601.097997
Perry M. Elliott, Juan R. Gimeno, María T. Tomé, Jaymin Shah, Deirdre Ward, Rajesh Thaman, Jens Mogensen, William J. McKenna, Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. European Heart Journal. ,vol. 27, pp. 1933- 1941 ,(2006) , 10.1093/EURHEARTJ/EHL041
Edward G Cape, Michael D VanAuker, Gunnlaugur Sigfússon, Theresa A Tacy, Pedro J del Nido, Potential Role of Mechanical Stress in the Etiology of Pediatric Heart Disease: Septal Shear Stress in Subaortic Stenosis Journal of the American College of Cardiology. ,vol. 30, pp. 247- 254 ,(1997) , 10.1016/S0735-1097(97)00048-X
R Thaman, JR Gimeno, RT Murphy, T Kubo, B Sachdev, Jens Mogensen, PM Elliott, WJ McKenna, Prevalence and clinical significance of systolic impairment in hypertrophic cardiomyopathy Heart. ,vol. 91, pp. 920- 925 ,(2005) , 10.1136/HRT.2003.031161
Mark V Sherrid, David Z Gunsburg, Sonja Moldenhauer, Gretchen Pearle, Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy Journal of the American College of Cardiology. ,vol. 36, pp. 1344- 1354 ,(2000) , 10.1016/S0735-1097(00)00830-5
Mark V Sherrid, Farooq A Chaudhry, Daniel G Swistel, Obstructive hypertrophic cardiomyopathy: echocardiography, pathophysiology, and the continuing evolution of surgery for obstruction The Annals of Thoracic Surgery. ,vol. 75, pp. 620- 632 ,(2003) , 10.1016/S0003-4975(02)04546-0