Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET

摘要: Purpose To correlate proton magnetic resonance spectroscopy ( 1 H-MRS), dynamic contrast-enhanced imaging (DCE-MRI), and 18 F-labeled fluorodeoxyglucose positron emission tomography ([ F]FDG PET) of nodal metastases in patients with head neck squamous cell carcinoma (HNSCC) for assessment tumor biology. Additionally, pretreatment multimodality was evaluated its efficacy predicting short-term response to treatment. Methods Materials Metastatic nodes were imaged H-MRS, DCE-MRI, [ PET 16 newly diagnosed HNSCC, before Short-term patient radiological at 3 4 months. Correlations among H-MRS (choline concentration relative water [Cho/W]), DCE-MRI (volume transfer constant K trans ]; volume fraction the extravascular extracellular space v e redistribution rate k ep ]), (standard uptake value [SUV] total lesion glycolysis [TLG]) calculated using nonparametric Spearman rank correlation. predict responses, logistic regression analysis performed. Results A significant positive correlation found between Cho/W TLG (ρ = 0.599; p 0.031). correlated negatively heterogeneity measures standard deviation std( ) −0.691; 0.004) −0.704; 0.003). Maximum SUV (SUVmax) values strongly MRI 0.643; 0.007). Logistic indicated that SUVmean predictors Conclusion Pretreatment is feasible HNSCC metastases. combined parameters predictive