Targeting eukaryotic Rab proteins: a smart strategy for chlamydial survival and replication.

摘要: Summary Chlamydia, an obligate intracellular bacterium which passes its entire lifecycle within a membrane-bound vacuole called the inclusion, has evolved variety of unique strategies to establish advantageous niche for survival. This review highlights mechanisms by Chlamydia subverts vesicular transport in host cells, particularly hijacking master controllers eukaryotic trafficking, Rab proteins. A subset Rabs and interacting proteins that control recycling pathway or biosynthetic route are selectively recruited chlamydial inclusion membrane. By interfering with Rab-controlled steps, this pathogen not only prevents own degradation phagocytic pathway, but also creates favourable environment growth replication. Chlamydia, highly adapted successful pathogen, several redundant re-direct vesicles emerging from compartments carry molecules essential bacterial development. Although current knowledge is limited, latest findings have shed light on role course infections could open novel opportunities anti-chlamydial therapy.