Hepatitis C virus seropositivity and TNF superfamily receptors: sCD40, sFas--the new putative determinants of endothelial dysfunction in haemodialysis patients.

摘要: Abstract Introduction Hepatitis C virus (HCV) infection occurs frequently among haemodialysis (HD) patients and increases the risk of atherosclerosis. CD40 Fas belong to tumor necrosis factor receptor (TNFR) superfamily, which play a role in hepatocyte apoptosis during HCV infection. The aim present study was determine whether anti-HCV-seropositivity constitutes an additional for endothelial dysfunction HD patients, sCD40 sFas could be associated with dysfunction. Materials methods A total 69 stable 28 healthy controls were included this study. Patients divided into anti-HCV-seropositive (HCV[+], n = 18) anti-HCV- seronegative (HCV[-], n = 51). plasma markers: von Willebrand (vWF), thrombomodulin (TM), soluble adhesion molecules – sICAM-1, sVCAM-1 TNFRs assayed. Results showed significant increase levels TM, sVCAM-1, compared controls, all these parameters higher HCV[+] than HCV[-] patients. sICAM-1 concentrations group group. vWF however there no difference parameter between determined as independent variables whereas found determinants levels. Conclusions This that TNF superfamily receptors: are novel increased markers