Ethanol enhances the hemodynamic effects of felodipine.

摘要: The acute hemodynamic and pharmacokinetic interactions between the vasodilating/diuretic drugs ethanol felodipine, a 1,4-dihydropyridine calcium entry blocker, were assessed in 10 patients with untreated borderline hypertension. A non-intoxicating dose of or placebo was administered randomized, crossover, double-blind manner followed by felodipine 5 mg. Maximum effects occurred at four hours. Felodipine plus decreased mean (+/- SE) supine total peripheral resistance (13 +/- 2 vs 17 mmHg/L/min, p = 0.05) diastolic blood pressure (68 3 75 mmHg, less than associated increased heart rate (72 67 bpm, cardiac index (3.7 0.4 3.0 0.3 L/min/m2, more alone. Greater differences apparent standing pressure. Co-administration systolic (113 8 126 0.01) (69 82 to greater degree, but not altered (87 6 84 bpm). Substantial hour diuresis both treatments (807 806 169 ml). Adverse frequent most often (17 11) as result postural lightheadedness (5 1) related hypotension. bioavailability influenced ethanol. However plasma concentrations greatly exceeded expected concentrations, possibly due interaction grapefruit juice vehicle. Ethanol can enhance hemodynamics produce clinically relevant adverse effects.