Appetite and body weight regulation after bariatric surgery

摘要: Bariatric surgery continues to be remarkably efficient in treating obesity and type 2 diabetes mellitus a debate has started whether it should remain the last resort only or also used for prevention of metabolic diseases. Intense research efforts humans rodent models are underway identify critical mechanisms underlying beneficial effects with view towards non-surgical treatment options. This non-systematic review summarizes interprets some this literature, an emphasis on changes controls appetite. Contrary earlier views, surgery-induced reduction energy intake subsequent weight loss appear main drivers rapid improvements glycaemic control. The responsible suppression appetite, particularly face large loss, not well understood. Although number food choice, taste functions, hedonic evaluation, motivation self-control have been documented both rodents after surgery, their importance relative contribution diminished appetite yet demonstrated. Furthermore, none major candidate postulated mediating from gut other organs brain, such as hormones sensory neuronal pathways, confirmed yet. Future focus interventional rather than descriptive approaches models.