Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia.

摘要: The absolute content of CD34(+) cells in the peripheral blood 84 patients with myelofibrosis myeloid metaplasia (MMM) and 23 other Philadelphia-negative (Ph(-)) chronic myeloproliferative disorders (CMDs) was investigated. In MMM, median number circulating consistently high (91.6 x 10(6)/L; range, 0-2460 10(6)/L). Receiver operating characteristic curve analysis showed that 15 10(6)/L as a decision criterion for produced an almost complete discrimination between MMM out therapy Ph(-) CMDs (positive predictive value, 98.4%; negative 85.0%). higher numbers had significantly longer disease duration (P =.019) spleen volume index =.014), liver =.000), percentage immature =.020), blasts =.000). When were correlated use Dupriez risk stratification, increased from low-risk (median, 68.1 10(6)/L) to intermediate-risk 112.8 high-risk (median 666.1 (F = 4.95; P =.009). severity score on basis both myelodepletive characteristics disease, only myeloproliferation associated cell level 5.7; Overall survival interval blast transformation time shorter more than 300 =.005 and.0005, respectively). conclusion, allows be distinguished CMDs; it is strongly extent predicts evolution toward transformation.