Preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids
作者： Janis Jaunzems
DOI:
关键词:
摘要: Process for the manufacture of an ester or respective free acid a 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic formula (I) wherein - Y is H, F alkyl group having from 1 to 12 carbon atoms which optionally substituted by at least one halogen atom, aralkyl aryl group, R H organic residue, 2 which comprises submitting compound (II) as defined above X Cl, Br I, ' to reduction reaction using hydrogen donating in presence UV light. The compounds (I) are useful e.g. intermediates pharmaceuticals and agrochemicals.
lens.org 参考文章(8)
Thomas Zierke, Martin Sukopp, Joachim Rheinheimer, Sebastian Peer Smidt, Thomas Grote, Jan Klaas Lohmann, Sandra Loehr, Michael Rack, Michael Keil, Jochen Dietz, Process for preparing difluoromethylpyrazolyl carboxylates ,(2007)
Valentina Dichiarante, Maurizio Fagnoni, Angelo Albini, Eco-friendly hydrodehalogenation of electron-rich aryl chlorides and fluorides by photochemical reaction Green Chemistry. ,vol. 11, pp. 942- 945 ,(2009) , 10.1039/B904897A
Thomas Wollner, Sergii Pazenok, Jens-Dietmar Heinrich, Norbert Lui, Method for the regioselective synthesis of 1-alkyl-3-haloalkyl–pyroazole-4-carboxylic acid derivatives ,(2009)
Marc Labelle, Patrick Lacombe, Rejean Ruel, Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment ,(2000)
Anja Schwögler, Frank Schieweck, Siegfried Strathmann, Reinhard Stierl, Jan Rether, Joachim Rheinheimer, Thomas Grote, Frank Werner, Peter Schäfer, Oliver Wagner, Maria Scherer, Bernd Müller, Markus Gewehr, Carsten Blettner, Wassilios Grammenos, 1-methyl-3-difluoromethyl-pyrazol-4-carbonic acid-(ortho-phenyl)-anilides, and use thereof as a fungicide ,(2005)
Janis Jaunzems, Max Josef Braun, Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids ,(2011)
Max Josef Braun, Process for the preparation of esters of 4-fluorosubstituted 3-oxo-alcanoic acids ,(2008)
Jim I. McLoughlin, Marla J. Williams, Suzanne Metz, Deborah A. Mischke, Selected pyrazolyl derivatives ,(1995)