Induced mutagenesis : molecular mechanisms and their implications for environmental protection

摘要: Session I: Mutagen/DNA Interactions.- Mutagenic effects of nucleic acid modification and repair assessed by in vitro transcription.- Genetic bisulfite: Implications for environmental protection.- II: Infidelity Specificity.- DNA replication as a basis mutagenesis.- The specificity infidelity polymerase.- Replication mutagenesis irradiated single-strand phage DNA.- Mutational UV light: Influence excision the mutator plasmid pKM101.- III: Analysis Mutagenesis.- Regulation function cellular gene products involved chemical E. coli.- Differential sensitivity to certain DNA-damaging treatments, including 8-methoxypsoralen plus 340nm ultraviolet irradiation, between K-12 B/r strains Escherichia use DNA-repair deficient mutants Chinese Hamster ovary cells studying mechanisms testing mutagens.- IV: Mammalian Systems.- Variation response mutagens amongst normal repair-defective human cells.- Relationship cytotoxic mutagenic action chemicals radiation.- induction resistance alkylation damage mammalian Induced simian virus 40 infecting carcinogen-treated monkey V: Human Systems Environmental Protection.- chemically induced mutation single cell populations.- Adaptability microbial mutagenicity assays study problems concern.- Final Discussion.- Participants.