作者: Andrew Douglas Baxter , John Brew
DOI:
关键词:
摘要: A compound (preferably bufeniode, denopamine, fenoterol, ifenprodil, isoxsuprine, labetol, medroxalol, mesuprine, nylidrin, protokylol, ractopamine, ritodrine, salmefamol or sulfinalol) that has utility in the treatment prevention of a condition associated with T-cell proliferation is mediated by pro- and/or anti-inflammatory cytokines, and particular disease selected from group consisting rheumatoid arthritis, osteoarthritis, osteoporosis, chronic demyelinating such as multiple sclerosis, respiratory diseases asthma obstructive pulmonary disease, inflammatory bowel (IBD) ulcerative colitis Crohn’s dermatological conditions psoriasis, scleroderma atopic dermatitis, dental periodontal gingivitis, diabetic nephropathy, lupus nephritis, IgA nephropathy glomerulonephritis, systemic iupus erythomatosus (SLE), graft vs host pain condition, formula (I), wherein R1 H Me; R2 alkyl R3 Me, are -CH2- thereby forming ring; n 0 to 2; X CH2 O; two benzene rings each optionally substituted OH, OMe, halogen, NHCHO, NHSO2Me, CONH2, SOMe, OCH2O, CH2OH.