HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model

摘要: Background: Statins are thought to have tumorolytic properties, reducing angiogenesis by inhibiting pro-angiogenic factors and inducing apoptosis of mural pericytes within the tumor vascular tree. Materials Methods: An orthotopic mouse glioblastoma (GL-26) model was used investigate effect simvastatin on vasculature in vivo. GL-26 cells were implanted into striatum C5LKa mice treated with either control, low- or high-dose simvastatin. Brains analyzed for necrotic volume, apoptosis, morphology pericytic Results: Low-dose increased necrosis compared both control groups. High-dose vessel caliber along wall low-dose Conclusion: Simvastatin has a dual tumorigenesis. At high doses, it may worsen instead 'normalizing' angio-architecture, albeit low doses affect cell survival promoting apoptosis. such as simvastatin, lovastatin cerivastatin competitively inhibit HMG-CoA reductase, which reduces overall cholesterol levels (1). The potential properties these statins been noted decade. It reported that can growth migration human glioma vitro (2) vivo