Rectal cancer staging post neoadjuvant therapy – how should the changes be assessed?
作者： Adrian C Bateman , Eleanor Jaynes , Andrew R Bateman
DOI: 10.1111/J.1365-2559.2009.03292.X
关键词:
摘要: Aims:To compare the utility and reproducibility of tumour regression grade scoring systems during histopathological assessment rectal cancers resected after neoadjuvant (i.e. pre-operative) chemoradiotherapy. Methods results:? The features were assessed independently in 54 cancer resection specimens using three systems: Tumour Regression Grade (TRG), modified Rectal Cancer (m-RCRG) RCPath Dataset (RCPath) methods. Good interobserver agreement was achieved for all (? scores: TRG system 0.719, m-RCRG 0.734, 0.742). Both observers diagnosed complete little/no 11 cases (20% cases) four (11% cases), respectively. A mean 5.6 blocks/case taken lymph node yield 8.4/case. Conclusions:? All usable a diagnostic setting. clinical significance differing degrees is not yet universally agreed and, with this mind, provided optimum balance between applicability accurate recording low, moderate high regression, thus facilitating future clinicopathological studies outcome.
core.ac.uk
sci-hub.se 参考文章(16)
J Strassbourg, L Blomqvist, I. R Daniels, D Sebag-Montefiore, T Holm, R. J Heald, S. E Fisher, Mercury Study Grp, P Quirke, B Mason, P. D Peppercorn, B. J Moran, G Brown, Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study ,(2006)
J. M. D. Wheeler, E. Dodds, B. F. Warren, C. Cunningham, B. D. George, A. C. Jones, N. J. McC Mortensen, Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: correlation with rectal cancer regression grade. Diseases of The Colon & Rectum. ,vol. 47, pp. 2025- 2031 ,(2004) , 10.1007/S10350-004-0713-X
Anne-Marie Mandard, Frédéric Dalibard, Jean-Claude Mandard, Jacques Marnay, Michel Henry-Amar, Jean-François Petiot, Alain Roussel, Jacques-Henry Jacob, Philippe Segol, Guy Samama, Jean-Marie Ollivier, Sylvie Bonvalot, Marc Gignoux, Pathologic Assessment of Tumor Regression After Preoperative Chemoradiotherapy of Esophageal Carcinoma. Clinicopathologic Correlations Cancer. ,vol. 73, pp. 2680- 2686 ,(1994) , 10.1002/1097-0142(19940601)73:11<2680::AID-CNCR2820731105>3.0.CO;2-C
J. M. D. Wheeler, B. F. Warren, N. J. McC. Mortensen, N. Ekanyaka, H. Kulacoglu, A. C. Jones, B. D. George, M. G. W. Kettlewell, Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system. Diseases of The Colon & Rectum. ,vol. 45, pp. 1051- 1056 ,(2002) , 10.1007/S10350-004-6359-X
R Ryan, D Gibbons, J M P Hyland, D Treanor, A White, H E Mulcahy, D P O'Donoghue, M Moriarty, D Fennelly, K Sheahan, Pathological response following long‐course neoadjuvant chemoradiotherapy for locally advanced rectal cancer Histopathology. ,vol. 47, pp. 141- 146 ,(2005) , 10.1111/J.1365-2559.2005.02176.X
Filippo Marino, Alessandro Ambrosi, Mario Lise, Salvatore Pucciarelli, Paola Toppan, Maria Luisa Friso, Valentina Russo, Lara Pasetto, Emanuele Urso, Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Diseases of The Colon & Rectum. ,vol. 47, pp. 1798- 1807 ,(2004) , 10.1007/S10350-004-0681-1
Hanifa Bouzourene, Fred T. Bosman, Walter Seelentag, Maurice Matter, Philippe Coucke, Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy Cancer. ,vol. 94, pp. 1121- 1130 ,(2002) , 10.1002/CNCR.10327
W.G. McCluggage, M.Y. Walsh, C.M. Thornton, P.W. Hamilton, A. Date, L.M. Caughley, H. Bharucha, Inter‐ and intra‐observer variation in the histopathological reporting of cervical squamous in traepithelial lesion susing a modified Bethesda grading system British Journal of Obstetrics and Gynaecology. ,vol. 105, pp. 206- 210 ,(1998) , 10.1111/J.1471-0528.1998.TB10054.X
R. Glynne-Jones, S. Mawdsley, J. R. Novell, The clinical significance of the circumferential resection margin following preoperative pelvic chemo-radiotherapy in rectal cancer: why we need a common language. Colorectal Disease. ,vol. 8, pp. 800- 807 ,(2006) , 10.1111/J.1463-1318.2006.01139.X
C.A.M. Marijnen, I.D. Nagtegaal, E. Klein Kranenbarg, J. Hermans, C.J.H. van de Velde, J.W.H. Leer, J.H.J.M. van Krieken, , No Downstaging After Short-Term Preoperative Radiotherapy in Rectal Cancer Patients Journal of Clinical Oncology. ,vol. 19, pp. 1976- 1984 ,(2001) , 10.1200/JCO.2001.19.7.1976