Congenital NOS2 Deficiency Protects Mice from LPS-induced Hyporesponsiveness to Inhaled Nitric Oxide
作者： Jörg Weimann , Kenneth D. Bloch , Masao Takata , Wolfgang Steudel , Warren M. Zapol
DOI: 10.1097/00000542-199912000-00028
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摘要: BackgroundIn animal models, endotoxin (lipopolysaccharide) challenge impairs the pulmonary vasodilator response to inhaled nitric oxide (NO). This impairment is prevented by treatment with inhibitors of NO synthase 2 (NOS2), including glucocorticoids and L-arginine analogs. However, because these in
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