Coupling of prefrontal gamma amplitude and theta phase is strengthened in trace eyeblink conditioning.

摘要: Trace eyeblink conditioning requires animals to associate a neutral stimulus (CS) and an aversive periorbital shock (US) that occurred moment later. Acquisition in this depends on several forebrain regions including the hippocampus, medial prefrontal, entorhinal cortices addition cerebellum. Activities of single population neurons these show patterns change with conditioning. For example, power synchronization theta oscillations are correlated rate acquisition. Yet, little is known about how neuronal at other frequency bands The present study examined changes gamma oscillations, which typically associated spiking activity individual cells. We found after CS offset 35-45 Hz fluctuated 7 Hz. This rhythmic fluctuation was observed all three locked local 4-8 Furthermore, over course 10 days acquisition sessions, coupling phase became stronger prefrontal cortex while it did not hippocampus or lateral cortex. Neither nor any significantly changed across rejecting possibility increase theta-gamma secondary power. between different sessions. These results suggest become more effectively coordinated concurrent trace may result impact firing responses processing down-stream regions, such as and/or pontine nuclei.