Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders
作者： Luiz Gustavo Piccoli de Melo , Sandra Odebrecht Vargas Nunes , George Anderson , Heber Odebrecht Vargas , Décio Sabbattini Barbosa
DOI: 10.1016/J.PNPBP.2017.04.027
关键词:
摘要: This review examines the shared immune-inflammatory, oxidative and nitrosative stress (ION reduced levels of high-density lipoprotein (HDL-c) cholesterol. Insulin resistance is probably not a major factor associated with mood disorders. Given high IO&NS metabolic dysregulation in BD MDD comorbidity atherogenic components MetS, disorders should be viewed as systemic neuro-IO&NS-metabolic The IO&NS-metabolic biomarkers may have prognostic value contribute to development novel treatments targeting neuro-immune, neuro-oxidative neuro-nitrosative pathways.
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