An update on electrophoretic and chromatographic methods in the diagnosis of hemoglobinopathies

摘要: This review primarily deals with methods for separations of hemoglobins. An introduction considers electrophoretic as well those involving isoelectric focusing and chromatography. The main advantages or disadvantages each procedure are discussed after technical description. chromatographic mainly limited to used in clinical biochemistry. second section treats the diagnostic problems typically met field hemoglobinopathies successively diagnosis adult newborn. Numerous variants have been described adult, among them Hb-S Hb-C most frequent. Unstable high oxygen affinity hemoglobin also considered. Finally, a new strategy is proposed. A special devoted thalassemia syndromes. prenatal some detail view preventing birth homozygous children. update ends chapter on interest assay hemoglobins A1c pathology diabetes mellitus.