The alterations in SATB1 and nuclear F-actin expression affect apoptotic response of the MCF-7 cells to geldanamycin
作者： Dariusz Grzanka , Magdalena Izdebska , Anna Klimaszewska-Wisniewska , Maciej Gagat
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摘要: Introduction. The function and localization of actin in the nucleus have not yet been fully described. However, seems to be a key protein nuclear processes interacting with chromatin matrix proteins. aim study was evaluate effect controlled expression pool F-actin special AT-rich sequence-binding 1 (SATB1) on vitro induction active cell death by geldanamycin (GA). Material methods. SATB1 regulated transfection non-aggressive breast cancer MCF-7 cells siRNA against or plasmid cloned cDNA SATB1. altered cofilin-1 these used regulate F-actin. GA analyzed context cycle alterations. Results. Our studies revealed that targeted regulation changed apoptotic response GA. overexpression proteins potentiated GA-induced arrest G1 phase increased population hypodiploid cells. Conclusion. alterations may affect their
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