Mrna Granules And Ischemic Preconditioning
作者： Michelle Rei Smith
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摘要: mRNA GRANULES AND ISCHEMIC PRECONDITIONING by MICHELLE R. SMITH December 2012 Advisor: Donald J. DeGracia, Ph.D. Major: Physiology Degree: Master of Science Brain ischemia and reperfusion that occurs after stroke cardiac arrest, causes translation arrest (TA) in neurons which is irreversible will undergo delayed neuronal death. TA linked to granules, are involved ischemia-induced stress genes translation. Ischemic preconditioning (IPC) the most protective response known protects from a lethal ischemic insult. In this thesis I studied effects (1) sublethal durations ischemia, (2) IPC (3) cycloheximide (CHX) on formation granules at 1 hour colocalization HuR granules. All tested, 2 8 min caused colocalized lower CA1 neurons. However, appeared attenuate did not enhance colocalization. CHX inhibited reperfusion, but had no effect animals subjected prior IPC. These results show cause behave similarly CA3 granule appears be less important 10 preconditioned animals. period
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