Display scaffolds: protein engineering for novel therapeutics.

摘要: Protein scaffolds represent a new generation of universal binding frameworks for use as future immunopharmaceuticals to complement the expanding repertoire therapeutic monoclonal antibodies. Here, we review recent literature describing advances in protein scaffold development, including efforts engineer minimal immunoglobulin-based binding-domain and molecular library design. Several diverse folds are currently under development on basis modular construction, strategy also observed families naturally evolved immune receptors. We describe potential intracellular applications where scaffold-specific features provide distinct advantages targeting non-conventional antigens comment scientific progress validation several designed voyage towards first-in-human trials.