Antibodies to von Willebrand factor in von Willebrand disease

作者: P. M. Mannucci , A. B. Federici

DOI: 10.1007/978-1-4613-0331-2_7

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摘要: The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) disease was first reported 2 consecutive studies by Sarji et al. (1974) and Stratton (1975). After this, 14 additional cases alloantibodies were described reviewed Mannucci Mari (1984). A survey carried out on behalf the World Federation Hemophilia identified 6 that, added to 15 previously reported, bring 21 total number patients so far anti-von (Mannucci Cattaneo, 1991). In frame survey, Hanna (1989) antibody towards VIII (F.VIII) girl disease. Since this did not apparently react factor, it will be here.

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