Early parental death and psychosocial risk factors for dementia: A case-control study in Europe.

摘要: OBJECTIVES To assess the association between early parental death and risk of dementia in adult life to examine factors associated with people without dementia. METHODS/DESIGN A population-based case-control study a sample 65 997 participants from Survey Health, Ageing Retirement Europe study. Early was operationalized as at age ≤16 years. Main analyses were conducted using bivariate multivariate logistic regression analyses. RESULTS The odds ratio (OR) for individuals who experienced (father or mother) ≤16 years 1.83 (95%CI 1.61-2.09) 1.54 1.35-1.76) adjusted age, gender education. In analysis carried out whole sample, increased (OR = 1.50, 95%CI 1.31-1.72), along older 5.92, 4.86-7.17), neuroticism 2.94, 2.61-3.31), low education level 1.84, 1.64-2.05) income 1.49, 1.34-1.67). DISCUSSION (≤16 years) an We discuss neurobiological markers adverse childhood experiences (ACEs) well interventions counteract negative health effects on adults. J Am Geriatr Soc 68:-, 2020.