Preoperative Gemcitabine and Cisplatin Followed by Gemcitabine-Based Chemoradiation for Resectable Adenocarcinoma of the Pancreatic Head
作者： Gauri R. Varadhachary , Robert A. Wolff , Christopher H. Crane , Charlotte C. Sun , Jeffrey E. Lee
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摘要: Purpose We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) pancreaticoduodenectomy (PD) for patients with stage I/II pancreatic adenocarcinoma. Patients Methods Chemotherapy consisted (750 mg/m 2 ) (30 given every weeks four doses. Chemoradiation weekly infusions (400 combined radiation therapy Gy 10 fractions administered over weeks) delivered 5 days per week. underwent restaging 4 6 after completion and, the absence disease progression, were taken surgery. Results The study enrolled 90 patients; 79 (88%) completed chemo-chemoradiation. Sixty-two (78%) surgery 52 (66%) PD. median overall survival all was 17.4 months. Median who chemo-chemoradiation 18.7 months, 31 months PD 10.5 27 did not undergo surgical resection their primary tumor (P .001). Conclusion Preoperative Gem-Cis-XRT improve beyond that achieved gemcitabine-based (Gem-XRT) alone. longer interval required more durable biliary decompression (metal stents) but associated local progression. platform is reasonable foundation on which build future multimodality trials cancer incorporating emerging systemic therapies. J Clin Oncol 26:3487-3495. © 2008 by American Society Clinical Oncology
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