Characterization of anti-liver-kidney microsome antibody (anti-LKM1) from hepatitis C virus-positive and -negative sera.
作者： Ana M. Yamamoto , Daniele Cresteil , Jean C. Homberg , Fernando Alvarez
DOI: 10.1016/0016-5085(93)90657-X
关键词:
摘要: Abstract Background: Hepatitis C virus-related antibodies were found in sera positive for to liver/kidney microsome antibody, usually considered a marker of autoimmune hepatitis. The aim this study was analyze the specificity autoantibody from patients with and without hepatitis virus infection. Methods: Fifteen anti-hepatitis virus- anti-liver kidney microsome-positive compared 11 hepatitis, reactivity against rat human liver microsomal proteins, P450IID6 recombinant various synthetic peptides spanning 241–429 amino acids sequence P450IID6. Results: Ten bound proteins region between 72 458. These 254–271 peptide, some also recognized 321–351, 373–389 410–429 peptides. Four 15 fusion protein coded by full-length complementary DNA; 3 them reacted 72–456. Only 1 321–351 peptide. Conclusions: antigenic sites virus-positive different those
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