HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors.

摘要: Cytogenetically visible aberrations of chromosomal region 12q14-15 in a variety frequent benign human tumors reflect rearrangements the HMGI-C gene. The mechanisms by which gene contributes to tumorigenesis are mostly unknown, although frequently aberrant transcripts containing exons 1 3 and ectopic sequences from other genes due breaks within third intron detectable. This is first report analyzing tissue samples mainly mesenchymal origin highly sensitive polymerase-chain-reaction-based approach detecting expression. We found expression embryonic but no any several adult tissues tested except for two myometrial tissues. These data suggest that expressed during embryonal fetal development. Thus, its particular role tumor development may be at least rather than formation fusion transcripts.