Expression of 11β-Hydroxysteroid Dehydrogenase Isoenzymes in the Human Pituitary: Induction of the Type 2 Enzyme in Corticotropinomas and Other Pituitary Tumors

摘要: One of the defining biochemical features Cushing’s disease is a relative insensitivity to glucocorticoid (GC) feedback, but an analysis GC receptor has failed detect any major abnormalities. However, two isoenzymes 11β-hydroxysteroid dehydrogenase (11βHSD), either by converting cortisone (E) cortisol (F) (type 1) or conversely F E 2), play important prereceptor role in regulating corticosteroid hormone action at several sites. 11βHSD1 and -2 expression within anterior pituitary gland itself may modulate feedback autocrine level, we have speculated that this be deranged disease. Detection 11βHSD type 1 2 immunoreactive protein was performed using fluorescence immunohistochemistry. Double immunofluorescent studies were undertaken on normal define cellular localization antisera against GH, ACTH, LH, FSH, PRL, S100, nonhormonal marker folliculo-stellate cells. In pi...