Liver dysfunction in chronic heart failure: prevalence, characteristics and prognostic significance

摘要: Eur J Clin Invest 2011 Abstract Background  Although abnormal liver morphology and function have long been recognized, characterization importance of dysfunction in heart failure are poorly defined. This study sought to investigate the relevance circulating tests (LFTs) an unselected chronic (CHF) cohort. Materials methods  A total 1032 consecutive ambulatory patients with CHF were enrolled from 2000 2008. Clinical laboratory variables including LFTs collected at entry. Follow-up (median 36 months) was available 1002 (97·1%) patients. The endpoint defined as death any cause or transplantation. Hazard ratios (HR) for transplant-free survival estimated per log unit using Cox proportional hazard regression models sex-stratified data. Results  Sex-specific prevalence cholestatic enzyme elevation 19·2% opposed elevated transaminases 8·3%. Cholestatic enzymes, but not transaminases, significantly associated severity syndrome backward failure. recorded 339 (33·8%). T-Bil, γ-glutamyltransferase (GGT) alkaline phosphatase (ALP) adverse outcome bivariate models. Of these, GGT [HR 1·22 (1·06, 1·41); P = 0·006] ALP 1·52 (1·09, 2·12); P = 0·014] independently after adjustment a wide array clinical predictors. Conclusions  Liver is frequent characterized by predominantly profile that disease prognosis. Thus, we propose cardio-hepatic CHF. Future studies needed clarify exact mechanisms organ interaction.