Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats
作者： Gregory T. Collins , Matthew E. Zaks , Alyssa R. Cunningham , Carley St. Clair , Joseph Nichols
DOI: 10.1016/J.DRUGALCDEP.2011.03.015
关键词:
摘要: Abstract Background A longer acting, double mutant bacterial cocaine esterase (CocE T172R/G173Q; DM CocE) has been shown to protect mice from cocaine-induced lethality, inhibit the reinforcing effects of in rats, and reverse cocaine's cardiovascular rhesus monkeys. The current studies evaluated effectiveness CocE against, cardiovascular, convulsant, lethal male female rats. Methods Pretreatment were used determine vivo duration action for rats against occurrence changes, convulsion lethality associated with acute toxicity. Posttreatment evaluate capacity rescue large doses cocaine. In addition, studied if there any potential sex on or toxicity Results dose-dependently protected higher active up 4 h, shifting at least 10-fold right. addition recovering an otherwise dose cocaine, post-treatment also reversed There no sex-related differences Conclusions Together, these results support development treatment
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