Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin

摘要: Two factors led to the emergence of “cholinergic hypothesis geriatric memory dysfunction” (1): evidence that cholinergic blockade in human volunteers leads impaired acquisition new information (2,3) and demonstration loss cortical activity cell bodies basal forebrain patients dying with Alzheimer’s disease (4, 5, 6). It has been proposed it is rising pathways from cortex (including hippocampus) responsible for amnesia seen dementing illnesses (6). This view challenged (e.g., ref. 7). Cholinergic antagonists also block transmission at neurons intrinsic many subcortical areas projections noncortical areas; this may affect memory, either directly or via an influence on arousal attention. Furthermore, studies rats did not produce a correlation between magnitude across various nonimmunotoxic lesion techniques learning performance impairments (8).