[Double-blind evaluation of slow-release nicardipine using different methods of blood pressure measurement. Predictive value of the acute response to intravenous nicardipine].

摘要: Forty hypertensive patients (diastolic greater than 95 mmHg) were included after 15 days of a single blind placebo period in randomized controlled double-blind study to assess the antihypertensive effect new galenic form nicardipine (N) administered 50 mg b.i.d. for 3 weeks. They comprised 27 men and 13 women aged from 72 years (mean: 53 +/- 10). Blood pressure (BP) was measured hospital before morning drug intake by an automatic recorder (Sentron) supine position 30 minutes (min) mercury sphygmomanometer. Ambulatory BP assessed portable patient activated (Remler 2000). Mercury sphygmomanometer under N fell 160 21/104 6 mmHg 151 14/98 8 (n = 20; p less 0.01/p 0.01) whereas (P) respectively 158 14/103 156 20/102 9 (NS). Sentron 17/96 148 13/90 7 (p 0.001/p with no change P (152 12/93 14/93 NS). every min 12 hours revealed decrease (160 18/105 10 142 16/94 mmHg; 0.001) control group on diastolic 15/103 16/100 mmHg/NS/p 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)